Rabbit Anti-Human TRAILR4/DCR2 (ID) Affinity Purified pAb

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. This polyclonal antibody can be used for detection of DcR2 expression by Western blot at 1:1000 to 1:2000 dilution. Whole cell lysate from HeLa cells can be used as positive control. It is human, mouse, and rat reactive. For research use only.