Rabbit Anti-Human DRAK1 (NT) Affinity Purified pAb

Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases (1). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues (1). This polyclonal antibody can be used for detection of DRAK1 by Western blot at 1:500 to 1:1000 dilution. A431 or MOLT4 whole cell lysate can be used as positive control and an approximately 50 kDa band can be detected. It is human, mouse, and rat reactive, and has no cross responses to DRAK2, DAP or ZIP kinases. For research use only.