Rabbit Anti-Human ARC (NT) Affinity Purified pAb

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1). This polyclonal antibody can be used for detection of ARC by Western blot at 1:500 dilution. Whole cell lysate from HeLa cells can be used as positive control and an approximately 25 kDa band can be detected. It is human, mouse, and rat reactive. For research use only.