Rabbit Anti-Human F1A alpha (CT) Affinity Purified pAb

Antibodies

F1Ab antibody can be used for detection of F1Ab by Western blot at 0.5 to 1 ¨¬g/ml. An approximately 70 kDa band can be detected. It is human, mouse, and rat reactive.

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1AA and FEM1b. F1AA/FEM1A is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1AA is cleaved by CED-3 and caspase. FEM-1/F1AA associates with CED-4 and its mammalian homologue Apaf-1. Over expression of F1AA induces apoptosis. F1AA is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1AA is expressed in a variety of human and mouse tissues.

Human F1A alpha Peptide