Rabbit Anti-Human GRP15 (NT) Affinity Purified pAb

Human immunodeficiency virus (HIV) and related viruses require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively, ) were recently cloned (1, 2). This novel G protein-coupled receptor serves as corecptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1 (2, 3). The ligand for GPR15 has not been identified yet. This polyclonal antibody can be used for detection of GPR15/BOB by Western blot at 1:500 to 1:2000 dilution. Jurkat or A549 cell lysate can be used as positive control and an approximately 50 kDa band can be detected. It is human, mouse, and rat reactive. For research use only.