Rabbit Anti-Human IL-21 (IN) Affinity Purified pAb

A novel cytokine was recently identified in human and mouse and designated IL-21 (1), which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1, 2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3, 4). IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations. This antibody can be used for detection of IL-21 by Western blot at 0.5 to 1 ug/ml. Human HL-60 and THP-1 cell lysates can be used as positive control and an approximately 18 kDa band can be detected. For research use only.