Rabbit Anti-Human IL-27RA (NT) Affinity Purified pAb

Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-g and lymphotoxin-b that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned (1, 2). It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1 (1, 2). TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-g and Th1-dependent antibody IgG2a (1). TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes. This antibody can be used for detection of TCCR by Western blot at 0.5 to 1 mg/ml. Human spleen tissue lysate can be used as positive control and an approximately 70 kDa band can be detected. For research use only.