Rabbit Anti-Human APRIL (ED2) Affinity Purified pAb

Anti-APRIL (ED2) TALL-2, TRDL-1 Polyclonal Antibody.Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-relatedLeukocyte-expressed Ligand 2), and TRDL-1a (for TNF related death ligand 1a) in human and mouse (1-4). Two receptors for APRIL were recently identified and designated TACI and BCMA (5-7). APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death (1-7). APRIL and its close relative of BlyS and theirreceptors BCMA and TACI are involved in diseases of autoimmunity and cancer (8, 9).