Rabbit Anti-Human BAFFR (CT) Affinity Purified pAb

BAFF-R antibody is supplied as immunoaffinity chromatography purified IgG, 100 ug in 100 ul of PBS containing 0.02% sodium azide. Store at 4C, stable for one year. Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-eB and c-jun N-terminal kinase.

BAFF-R (CT) BR3.