Rabbit Anti-Mouse Akt1/PKB pAb

This polyclonal antibody, which reacts with mouse and human Akt/PKB, was generated using, E. coli -expressed mouse Akta (a.a. 375- 479) as an immunogen. Akt (also termed PKB, or RAC (Related to PKA and PKC), is the cellular homologue of the viral oncoprotein v-Akt. Akt is a serine / threonine kinases that consist of an N-terminal PH domain, a kinase domain and a C-terminal domain similar to that of the PKC family. Akta contains 480 amino acids, and can be activated by receptor tyrosine kinases through the PI 3-kinase pathway. Akt has been shown to suppress apoptosis. Recent study suggests that Akt may also be part of the NF-kB activation pathway.

Reconstitute to 1 mg/ml by adding 200 ml H2O