Recombinant Human IGF-1 (Leu60) Receptor Grade

Human [Leu60] Insulin-like Growth Factor-I ([Leu60]IGF-I) is an analog of human IGF-I with a Leu substitution in place of Tyr at position 60. Human [Leu60]IGF-I has greatly reduced binding to the Type 1 IGF receptor and to the insulin receptor compared to IGF-I, and a lower affinity than human [Leu24]IGF-I. However binding to acid-stripped human serum binding proteins is unaltered. Consequently human [Leu60]IGF-I is an extremely useful analog of IGF-I for investigating IGF actions largely independent of binding to the Type 1 IGF receptor.