Recombinant Human IGF1 (Ala31/Leu60) Receptor Grade

Human [Ala31][Leu60]Insulin-like Growth Factor-I ([Ala31][Leu60]IGF-I) is an analog of human IGF-I which has an Ala substitution in place of Tyr at position 31 and a Leu substitution in place of Tyr at position 60 of the human IGF-I sequence. [Ala31][Leu60]IGF-I has greatly reduced binding to the Type 1 IGF receptor and to the insulin receptor compared to IGF-I, [Leu24]IGF-I and [Leu60]IGF-I. However [Ala31][Leu60] IGF-I has normal binding to acid-stripped human serum binding proteins. Consequently [Ala31][Leu60]IGF-I is an extremely useful analog of IGF-I for investigating IGF actions largely independent of binding to the Type 1 IGF receptor.