Recombinant Human BMP-13

The lyophilized protein is best stored desiccated below 0C. Reconstituted protein should be stored in working aliquots at -20C. Avoid repeated freeze-thaw cycles.

BMPs (bone morphogenetic proteins) belong to the TGF-b superfamily of structurally related signaling proteins. These ligands mediate numerous physiological processes. BMPs initiate, promote and maintain cartilage and bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Expression of BMP-13 has been found in the hypertrophic chondrocytes of ossifying long bone centers. Recombinant human BMP-13/CDMP-2 is a 27 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids polypeptide chains.

Centrifuge vial prior to opening. The human BMP-13 should be reconstituted in water containing BSA (50 ug BSA per 1 ug protein) to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions and stored for 1 week at 2-4C or at -20C for future use. Note: Due to solubility reasons, the protein should be kept at a low pH.

<0.1 ng per ug of BMP-13.