« Back
Home /
Human Recombinant FGFR-1 / Fc Chimera, soluble

Human Recombinant FGFR-1 / Fc Chimera, soluble

Manufacturer	Cell Sciences
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Regulation of Appetite Neural Signaling Neural Adhesion Molecules By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Astrocytoma By Organ Bladder Cancer Colorectal Cancer Calcium Binding Protein Markers Interneuron Markers
Type	Proteins
Specific against	Human
Amount	10 ug
Host	Insect
Item no.	CS-CRF016A
Targets	FGFR4, CD331, TYK2, FGF2
Conjugate/Tag	Fc
eClass 6.1	34160400
eClass 9.0	42020190
Available
Biological Activity	Determined by its ability to inhibit human FGF acidic-dependent proliferation on R1 cells. The ED50 for this effect is typically 15.0-30.0 ng/ml.
Description	Recombinant human soluble FGFR-1a (IIIc) was fused via a Xa cleavage site with the Fc part of human IgG1. Human recombinant soluble FGFR-1a (IIIc)/Fc is a disulfide-linked heterodimeric protein. The reduced form of human FGF-R1a (IIIc)/Fc is a monomer with a calculated, ca.66 kDa. As a result of glycosylation, the recombinant protein has a mass of 90-95 kDa. Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.
Endotoxin Level	< 0.1 ng per ug of sFGF-R1a
Formulation	Lyophilized
Molecular Weight	190 kDa
Reconstitution	Centrifuge vial prior to opening .Reconstitute sFGFR-1a (IIIc)/Fc in PBS or medium to a concentration not lower than 50 ug/ml.Human sFGFR-1a (IIIc)/Fc is soluble in water and most aqueous buffers.
Storage and Stability	The lyophilized product is stable for more than six months when kept at <=-20C.The reconstituted product should be stored in working aliquots at -20C to -80C. Avoid repeated freeze-thaw cycles .

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.