Recombinant Human GSK3 beta GST Active

Stable for 1 year in working aliquots at -80C. Avoid repeated freeze-thaw cycles.

Recombinant Human full length GSK3B with N-terminal GST tag. GSTK3B is a serine threonine protein kinase that was originally identified as the kinase that phosphorylates and inhibits glycogen synthase. GSK3B is ubiquitously present in human tissues and implicated in the regulation of several physiological processes, including the control of glycogen and protein synthesis by insulin, and modulation of the transcription factors AP-1 and CREB. Transient transfection of human GSK3B into CHO cells stably transfected with individual human tau isoforms leads to hyperphosphorylation of tau at all the sites investigated with phosphorylation-dependent anti-tau antibodies.

>100 nmol/min/mg (lot specific) as determined by Kinase Activity Assay