Recombinant Human IL-17B

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 155 amino acid chains, secreted by activated T-cells and acts on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region and differ from one another in their Nterminal segments and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. The IL-17B has the ability to activate the release of TNF-alpha and IL-1 beta from monocyclic cell line THP-1. Recombinant human IL-17B is a disulfide-linked homodimer, consisting of two 161 amino acid polypeptide chains.