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Recombinant Human IL-31

Recombinant Human IL-31

Manufacturer	Cell Sciences
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Neural Transcription Factors Targets for Rodent Neurosciences Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines By Organ Skin Cancer Hepatic Cancer
Type	Proteins
Specific against	Human
Amount	5 ug
Host	E.coli
Item no.	CS-CRI201A
Targets	LGALS3, IL31
eClass 6.1	34160400
eClass 9.0	42020190
Available
Biological Activity	Fully biologically active when compared to standard. The specific activity is determined by inducing STAT3 activation of U-87 MG human glioblastoma/astrocytoma cells. 5 ng/mL of rHuI-L31 can effectively induce STAT3 activation.
Description	Human Interleukin-31 (IL-31) is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
Endotoxin Level	Less than 1EU/ug of rHuIL-31 as determined by LAL method.
Formulation	Lyophilized from a 0.2um filtered concentrated solution in PBS, pH7.4.
Molecular Weight	15.8 kDa
Reconstitution	Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability	Stable at 2-8C, but best kept desiccated -20C. Upon reconstitution, stable for up to 1 week at 2-8C. For longer term, store in working aliquots below -20C. Avoid repeated freeze/thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 ug

available

Delivery expected until 5/9/2024