Recombinant Human NKp46

Recombinant Human Natural Cytotoxicity Receptor NKp46 is a single, non-glycosylated polypeptide chain containing 235 amino acids. Natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NK cells, and NKp44, which is expressed only on activated NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. The lysis of tumor cells by NK-cells involves recognition by NKp46 of membrane heparan sulfate proteoglycans. Furthermore, NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 has two extracellular Ig-like domains followed by a ca.40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. Reduced cell surface expression of NKp46 and other NK-cell receptors is linked to the impaired NK-cell cytolytic function in viremic HIV-1 infection.

26.6 kDa