Recombinant Human TNF-alpha (aa 77-233) His

Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Please avoid freeze thaw cycles.

Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer. Tumor Necrosis Factor-a Human Recombinant His produced in, E. coli, is a single, non-glycosylated, polypeptide chain containing 157 amino acids fragment (77-233) and having a MW = 21.85 kDa with an amino-terminal hexahistidine tag.