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Recombinant Human Tissue Plasminogen Activator

Recombinant Human Tissue Plasminogen Activator

Manufacturer	Cell Sciences
Category	Food Safety Proteins Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	Human
Amount	100 ug
Host	CHO cells
Item no.	CS-CRT171B
eClass 6.1	34160400
eClass 9.0	42020190
Available
Concentration	1 mg/ml
Description	Tissue Plasminogen Activator (tPA/PLAT) is a secreted serine protease that converts the proenzyme Plasminogen to Plasmin, a fibrinolytic enzyme. tPA is synthesized as a single chain which is cleaved by Plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding. Decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Recombinant Human tPA is >95% two-chain and is activated from the single-chain form with immobilized Plasmin. It has 100% complex formation with Human PAI1.
Formulation	Frozen Liquid in 0.4 M HEPES + 0.1 M NaCl, pH 7.4
Molecular Weight	70 kDa
Storage and Stability	Store in working aliquots at -80C. Product is stable for 3 years from date of delivery when stored as directed. Avoid repeated freeze-thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.