Recombinant Human UBE2K/HIP2 His

Store at 2-4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Avoid repeated freeze thaw cycles.

Ubiquitin-Conjugating Enzyme EK2 (UBE2K) belongs to the ubiquitin-conjugating enzyme family which take part in many cellular processes such as selective protein degradation, DNA repair, cell cycle control, and sporulation. UBE2K interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. UBE2K produced is a single, non-glycosylated polypeptide chain containing 236 amino acids (aa 1-200) fused to a 36 amino acid His-tag at the N-terminus. It is purified by proprietary chromatographic techniques.