Recombinant Human ERBB3 His

This liquid suspension is stable for several months at 2-4C, but should be kept at -20C for long term storage. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles.

ErbB3, also called Her3 (human epidermal growth factor receptor 3), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. Among ErbB family members, ErbB3 is unique in that it contains a defective kinase domain. ErbB3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric ErbB3 serves as a low affinity receptor for the heregulins (HRG). rhErbB3-f is a recombinant genetic engineering product which expressed in, E. coli, . RhErbB3-f can induce specific antibody production, in vivo , hence to inhibit tumor cell growth. The product can be used to treat early, medium and advanced or post-operative breast cancer patients with over-expression of ErbB2. According to its mechanism of action, rhErbB3-f is classified into therapeutic cancer vaccine.

Fully biologically active when compared to standard. The specific activity is determined by postponing tumor emerge time of spontaneous breast cancer in FVB/N transgenic mice and inhibiting the development of tumor, effectively inhibit the growth of in situ transplanted breast cancer in FVB/N transgenic mice.