Native Human Alpha 1-Antitrypsin/Serpin A1

Store at 2-4C. 1 year.

Human Alpha-1-AntiTrypsin (A1AT), also known as serum trypsin inhibitor, is a serine protease inhibitor (serpin) and trypsin inhibitor. A1AT protects tissue from enzymes from inflammatory cells, especially Elastase, and is present in human blood. Disorders of the enzyme include Human Alpha-1-AntiTrypsin Deficiency, a hereditary condition in which the absence of A1AT leads to uninhibited tissue breakdown during inflammation. Studies indicate that this causes pulmonary emphysema and leads to liver cirrhosis in severe cases. Human A1AT protects the lungs from the harmful effects of Human Neutrophil Elastase.

0.05 M phosphate buffer pH>7 + 0.15 M NaCl