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Native Human PAI1/tPA Double Depleted Plasma *di

Native Human PAI1/tPA Double Depleted Plasma *di

Manufacturer	Cell Sciences
Category	Oncology Food Safety Proteins Cell Biology Cell Status Senescence Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Biological Samples Plasma By Organ Breast Cancer
Type	Biological Fluids
Specific against	Human
Amount	10 ml
Host	Human
Item no.	CS-CSI19816A
Targets	SERPINE1, AGT
eClass 6.1	32160401
eClass 9.0	34480105
Available
Concentration	<1.0 ng/mL PAI1 Antigen, <1.0 ng/mL tPA Antigen
Description	Plasminogen Activator Inhibitor 1 (PAI1) is the principal inhibitor of Tissue Plasminogen Activator (tPA) and Urokinase (uPA), the activators of Plasminogen and hence fibrinolysis. It is a serine protease inhibitor (serpin) protein (SERPINE1). PAI1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue. Tissue Plasminogen Activator (tPA/PLAT) is a secreted serine protease which converts the proenzyme Plasminogen to Plasmin, a fibrinolytic enzyme. tPA is synthesized as a single chain which is cleaved by Plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.
Formulation	Frozen Liquid
Storage and Stability	Store at -70C.
Specificity	<0.3 ng/mL PAI1 Antigen, <0.2 ng/mL tPA Antigen

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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