Recombinant Human IGF1 (Arg3) Receptor Grade

Human [Arg3]Insulin-like Growth Factor-I ([Arg3]IGF-I) is a 70 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence [Arg3]). GroPep scientists have engineered this analog with the express purpose of increasing biological activity. Human [Arg3]IGF-I is significantly more potent than human IGF-I in vitro and in vivo. It is offered to customers who prefer a full length IGF rather than the truncated human Des(1-3)IGF-I which has similar properties. The enhanced potency is due to the markedly decreased binding of human [Arg3]IGF-I to all IGF binding proteins which normally inhibit the biological actions of IGFs.