Synthetic PTMA/Thymosin-alpha 1/Thymalfasin

Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Thymalfasin should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of mouse T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity. Thymosin a1 acetate, also known as thymalfasin has immunoregulatory properties enhancing immune functions.

It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18 MU-cm water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.