Recombinant HTLV-I gp46 Mosaic (aa 162-214; 242-257)

HTLV-1 gp46 although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cells called Th1 cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependent response (these include parasitic infections and production of mucosal and humoral antibodies). The, E. coli, derived recombinant mosaic protein contains the gp46 immunodominant regions, 162-214 amino acids and 242-257 amino acids, Mw on SDS-PAGE is 39 kDa.