Recombinant HTLV-I Mosaic (aa 374-400;190-207)

HTLV-1 Mosaic although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cells called Th1 cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependent response (these include parasitic infections and production of mucosal and humoral antibodies). The, E. coli, derived recombinant mosaic protein contains the gp21 and gp46 immunodominant regions, 374-400 amino acids and 190-207 amino acids, the MW is 42 kDa. The protein is fused with GST at N-terminus.

Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.