Recombinant Rat tPA, two chain Active *di

>95% two chain, >95% active.

Recombinantly produced in insect cells. Activated from single-chain form with immobilized plasmin. >95 percent two chain, >95 percent active.PLAT is a secreted serine protease which converts the proenzyme Plasminogen to the fibrinolytic enzyme Plasmin. PLAT is synthesized as a single chain which is cleaved by Plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.

70 kDa