Jiyoye Cells

Analysis of B cell surface antigens, testing of cytotoxic drugs, mutational analysis, analysis of apoptotic mechanisms, haplotype standard.

The Jiyoye cell line is an extensively studied model derived from a human Burkitt lymphoma. Burkitt lymphoma is a type of non-Hodgkin lymphoma that predominantly affects B cells, and the Jiyoye cell line retains many of the key characteristics of this malignancy. The cells exhibit the typical chromosomal translocation between the c-MYC gene and immunoglobulin gene loci, which is a hallmark of Burkitt lymphoma. This translocation leads to the overexpression of the c-MYC oncogene, driving the proliferative and aggressive nature of the tumor cells. As such, the Jiyoye cell line is an invaluable tool for studying the molecular and genetic mechanisms underlying lymphomagenesis, especially in the context of MYC-driven cancers.

Jiyoye cells grow in suspension and are characterized by their high proliferation rate, which makes them suitable for a variety of experimental applications, including drug screening, gene expression studies, and apoptosis assays. The cell line is also frequently used in research focusing on Epstein-Barr virus (EBV), as Burkitt lymphoma cells, including Jiyoye, often harbor this virus, which is implicated in the pathogenesis of the disease. This makes Jiyoye particularly useful for investigating the interplay between viral oncogenes and cellular pathways in B cell malignancies.

Given its origin and characteristics, the Jiyoye cell line is a critical model for oncological research, particularly in understanding the pathophysiology of B cell lymphomas. However, it is important to note that this cell line is intended for research purposes only and is not suitable for therapeutic or in vivo applications.

Suspension

B-cell Non-Hodgkin-Lymphoma

Male

1

Supplement the medium with 10% FBS

2 to 3 times per week

CM-1 (Cytion catalog number 800100)

Mycoplasma contamination is excluded using both PCR-based assays and luminescence-based mycoplasma detection methods.
To ensure there is no bacterial, fungal, or yeast contamination, cell cultures are subjected to daily visual inspections.

Our cells are provided for in vitro laboratory research purposes exclusively and are not intended for clinical or diagnostic use, nor are they to be administered to humans or used for veterinary purposes. Users must adhere to all applicable guidelines and regulations for the handling and use of these cells in a research setting.

X, Y

B-Lymphocyte

46, hypodiploid