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Fasudil hydrochloride

Fasudil hydrochloride

Item no.	CD0160-250
Manufacturer	Chemdea
Amount	250 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HA-1077, ROCK inhibitor
Available
Inhibitor Function	ROCK Inhibitor
Description	A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µ M), protein kinase G (Ki = 1.6 µ M), and myosin light chain kinase (Ki = 3.6 µ M). Also reported to potently inhibit Rho-associated kinase (ROCK, IC50 = 10.7 µ M). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
Purity	99% by HPLC.
CAS #	938440-64-3
Solubility	Water (200 mg/mL), DMSO (10 mg/mL).
Molecular Formula	C₁₄H₁₇N₃O₂S&bull, 2HCl
Molecular Weight	364.3
Notes	White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS.
Reference	1. Watanabe, K. et al. Nature Biotech. 2007, 25, 681 2. Swärd, K. et al. J. Physiol. 2000, 522, 33 3. Takizawa, S. et al. Eur. J. Pharmacol. 1993, 250, 431 4. Seto, M. et al. Eur. J. Pharmacol. 1991, 195, 267 5. Shirotani, M. et al. J. Pharmacol. Exp. Ther. 1991, 259, 738 6. Asano, T. et al. Eur. J. Pharmacol. 1990, 190, 365 7. Sasaki, Y., and Sasaki, Y. Biochem. Biophys. Res. Commun. 1990, 171, 1182 8. Asano, T. et al. Br. J. Pharmacol. 1989, 98, 1091.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 11/6/2025

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