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TGX-221

TGX-221

Item no.	CD0180-100
Manufacturer	Chemdea
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PI 3-Kbeta Inhibitor VI
Available
Inhibitor Function	PI3Kb Inhibitor
Description	A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kb (p110β IC50 = 0.005 µ M, p110&delta, IC50 = 0.1 µ M, p110α IC50 = 5 µ M, and p110β IC50 >=3.5 µ M) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µ M. An excellent tool for studying p110β -dependent responses both in cells in vitro and in animals in vivo.
Purity	98% by HPLC.
CAS #	663619-89-4
Solubility	DMSO (10 mg/mL), ethanol (5 mg/mL)
Molecular Formula	C₂₁H₂₄N₄O₂
Molecular Weight	364.44
Notes	White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS.
Reference	1. Chaussade, C., et al. Biochem. J. 2007, 404, 449 2. Cosemans, J. M, et al. Blood 2006, 108, 3045 3. Condliffe, A.M., et al. Blood 2005, 106, 1432 4. Jackson, S.P., et al. Nat. Med. 2005, 11, 507.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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Delivery expected until 11/6/2025

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