Rat Albumin Detection Kit

ELISA

Gel Packs

Nephritis animal models / SLE animal models

Albumin is the most abundant protein in plasma, accounting for more than half of the measured serum protein. It consists of a single polypeptide chain of 585 amino acids with a molecular weight of 66.5 kDa. Because of its high molecular weight and concentration in plasma, albumin is critical in maintaining plasma osmotic pressure. In human, plasma albumin levels are significantly decreased in patients with severe liver disease or poor nutritional status, since albumin synthesis takes place exclusively in the liver. Alternatively, low plasma albumin levels occur due to increased capillary leakage caused by critical illnesses such as kidney disease, inflammation, sepsis, and major surgical stress. In addition, excretion of albumin into urine (albuminuria) is very low in healthy individuals, but it is significantly increased by renal damage in glomerulonephritis and diabetic nephropathy. In fact, rat disease models of sepsis, glomerulonephritis and diabetic nephropathy demonstrate comparable albuminuria with human patients, suggesting that rat urinary albumin levels are useful for evaluating disease severity and treatment efficacy.

Serum, Plasma