Comparison

Anti Collagen Alpha-1(XVII) Chain (BP180/BPAG2) mAb (Clone C34)

Item no. CAC-NU-01-BP2
Manufacturer Cosmobio
Amount 500 ul
Category
Type Antibody Monoclonal
Applications WB, IF, IP, IHC
Clone C34
Specific against Human (Homo sapiens)
Host Mouse
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Available
Manufacturer - Applications
IP, IF, WB, IHC(f)
Manufacturer - Category
Antibodies/Cytoskeleton/Primary Antibodies; Antibodies/Primary Antibodies/Cytoskeleton; Research Area/Cell Biology/Cell Adhesion & Migration/Primary Antibodies; Research Area/Cell Biology/Cytoskeleton/Primary Antibodies; Research Area/Cell Types/Epithelial Cells/Primary Antibodies; Research Area/Disease/Epidermolysis bullosa/Primary Antibodies; Research Area/Disease/Epithelial recurrent erosion dystrophy/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Desmosomes/Primary Antibodies; Research Area/Cell Biology/Extracellular Matrix/Primary Antibodies
Storage Conditions
-20°C
Maker
CAC
Antigen/Source
BP180/type XVII collagen
Description
Hemidesmosomes are adhesive structures between cells and the extracellular matrix. They play a role in anchoring intermediate fibers to the extracellular basement membrane. Structurally, hemidesmosomes occur in two forms: Type I and Type II. Type I hemidesmosomes develop in stratified epithelia such as the epidermis. Its main components include the intracellular linker proteins Plectin and BPAG1, the adhesion receptor integrin α 6β 4 and collagen type BP180/XVII. Type II hemidesmosomes occur in blood vessels, Schwann cells, and digestive tract epithelia as a simplified form of Type I hemidesmosomes, consisting only plectin and integrin α 6β 4. The hemidesmosomal adhesion receptor is normally associated with Laminin 5 in the basement membrane. Furthermore, Laminin 5 (of which Laminin gamma 2 is a subunit) is linked to collagen fibers in the dermis via type VII collagen. Genetic deletion of hemidesmosome-related proteins causes various forms of epidermolysis bullosa, highlighting their importance in promoting adhesion between the epidermis and the basement membrane.
Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa.
References:
1) Yamauchi T., et al. J. Dermatol. Sci., 76:25-33 (2014).
2) Hirako Y., et al. Exp. Cell Res., 324:172-182 (2014).
3) Hirako Y., et al. J. Baiol. Chem., 273:9711-9717 (1998).
Clonality
Monoclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 ul
Available: In stock
available

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