Anti Collagen Alpha-1(XII) Chain mAb (Clone 378D5)

Antibodies/Primary Antibodies/Extracellular Matrix; Antibodies/Abs For Paraffin Embedded Tissue/Extracellular Matrix; Antibodies/Extracellular Matrix/Abs For Paraffin Embedded Tissue; Antibodies/Extracellular Matrix/Primary Antibodies; Research Area/Cell Biology/Cell Adhesion & Migration/Primary Antibodies; Research Area/Cell Biology/Extracellular Matrix/Primary Antibodies; Research Area/Cell Biology/Cell Differentiation/Primary Antibodies; Research Area/Cell Biology/Cell Adhesion & Migration/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Extracellular Matrix/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Cell Differentiation/Abs For Paraffin Embedded Tissue; Research Area/Disease/Ullrich congenital muscular dystrophy/Abs For Paraffin Embedded Tissue; Research Area/Disease/Ullrich congenital muscular dystrophy/Primary Antibodies; Research Area/Disease/Bethlem Myopathy/Abs For Paraffin Embedded Tissue; Research Area/Disease/Bethlem Myopathy/Primary Antibodies

Type XII collagen is a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen subfamily currently composed of 9 members (collagen types VII, IX, XII, XIV, XVI, XIX, XX, and XXI). Type XII collagen is a homotrimer composed of three alpha-1(XII) chains with an approximate Mr of 220 kDa. This collagen was originally found in prevalent association with type I collagen in tendons, ligaments, perichondrium, and periosteum and all dense connective tissues, but more recent studies also document association of the collagen with basement membranes. The type XII-type I collagen connection is thought to modify the interactions between collagen type I fibrils and the surrounding matrix such as to create specific macromolecular configuration of the ECM. Alternatively spliced transcript variants encoding different isoforms of the collagen have been identified. Rotary shadowing/TEM analyses shows a structure with a thin 75-nm tail, which is frequently kinked, attached through a central globule to three finger-like projections, each 60 nm long.

Monoclonal