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TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases.This antibody is a powerful tool for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy. Specifications Important Notice About Format Change:Replacement for Cat No.: CAC-TIP-PTD-M01For lots "11-9-20" and newer, this antibody is now provided as ammonium sulfate precipitated culture supernate, formulated in 50% glycerol, 0.05% NaN3. Older lots were provided as raw culture supernate. Vials of the previous format remain available while supplies last. (posted: March 2020). This has improved sensitivity, and does not require altering current protocols.Recommended dilutions: Western blotting:1/1000-1/3000 Immunohistochemistry: 1/3000-1/10000 ELISA: 1/1000-1/5000 Other applications not tested Optimal dilutions/concentrations should be determined by end user.References Inukai Y, Nonaka T, Arai T, et al. Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett. 582, 2899-2904, 2008 PubMed: 18656473
This antibody is a powerful tool for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy. Specifications Important Notice About Format Change:Replacement for Cat No.: CAC-TIP-PTD-M01For lots "11-9-20" and newer, this antibody is now provided as ammonium sulfate precipitated culture supernate, formulated in 50% glycerol, 0.05% NaN3. Older lots were provided as raw culture supernate. Vials of the previous format remain available while supplies last. (posted: March 2020). This has improved sensitivity, and does not require altering current protocols.Recommended dilutions: Western blotting:1/1000-1/3000 Immunohistochemistry: 1/3000-1/10000 ELISA: 1/1000-1/5000 Other applications not tested Optimal dilutions/concentrations should be determined by end user.References Inukai Y, Nonaka T, Arai T, et al. Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett. 582, 2899-2904, 2008 PubMed: 18656473
Specifications Important Notice About Format Change:Replacement for Cat No.: CAC-TIP-PTD-M01For lots "11-9-20" and newer, this antibody is now provided as ammonium sulfate precipitated culture supernate, formulated in 50% glycerol, 0.05% NaN3. Older lots were provided as raw culture supernate. Vials of the previous format remain available while supplies last. (posted: March 2020). This has improved sensitivity, and does not require altering current protocols.Recommended dilutions: Western blotting:1/1000-1/3000 Immunohistochemistry: 1/3000-1/10000 ELISA: 1/1000-1/5000 Other applications not tested Optimal dilutions/concentrations should be determined by end user.References Inukai Y, Nonaka T, Arai T, et al. Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett. 582, 2899-2904, 2008 PubMed: 18656473
Recommended dilutions: Western blotting:1/1000-1/3000 Immunohistochemistry: 1/3000-1/10000 ELISA: 1/1000-1/5000 Other applications not tested Optimal dilutions/concentrations should be determined by end user.References Inukai Y, Nonaka T, Arai T, et al. Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett. 582, 2899-2904, 2008 PubMed: 18656473
References Inukai Y, Nonaka T, Arai T, et al. Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett. 582, 2899-2904, 2008 PubMed: 18656473
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
CAC-TIP-PTD-M01.pdf
CAC-TIP-PTD-M01-datasheet.pdf
CAC-TIP-PTD-M01-safety-datasheet.pdf
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