Anti Collagen 4 (ALPHA)5(IV) mAb (Clone B51)

Check out our Human Collagen IVα Rat Monoclonal Antibodies Dashboard for more information about this product and additional epitope-defined monoclonal antibodies useful for research on hereditary diseases related to collagen IV, including our popular Anti-Collagen 4 Cocktail mAb (Clones H53, B51, H25) (SGE-CFT45325).

Alport syndrome is an inherited disease characterized by the pathological absence or reduction of the collagen α 5(IV) chain in glomerular basement membrane (GBM), tubular basement membrane (TBM) and Bowman's capsular basement membrane. Anti Collagen 4 (ALPHA)5(IV) mAb (Clone B51) (cat no. SGE-C451) is an unlabeled version of one of three different rat mAbs included in Anti-Collagen 4 Cocktail mAb (Clones H53, B51, H25) (SGE-CFT45325) for easy and rapid staining of human renal and skin biopsy sections to distinguish Alport syndrome from normal tissue. Anti-Collagen 4 Cocktail mAb (Clones H53, B51, H25) comprises two different FITC-conjugated mAbs (clones H53 and B51) that reveal the Alport-affected α 5(IV) chain in glomerular, tubular and Bowman's capsular BMs and an internal positive control Texas Red-conjugated mAb (clone H25) that targets α 2(IV) to reveal endothelial basement membrane structure

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