Anti NG2 (CSPG4) mAb (Clone 2161D7)

Research Area/Glycobiology/Proteoglycans/Primary Antibodies; Research Area/Cell Biology/Signal Transduction/Primary Antibodies; Research Area/Disease/Melanoma/Primary Antibodies; Research Area/Cell Biology/Cell Adhesion & Migration/Primary Antibodies; Research Area/Cell Biology/Extracellular Matrix/Primary Antibodies; Glycobiology/Primary Antibodies/Proteoglycans; Antibodies/Abs For Paraffin Embedded Tissue/Proteoglycans; Antibodies/Proteoglycans/Abs For Paraffin Embedded Tissue; Glycobiology/Abs For Paraffin Embedded Tissue/Proteoglycans; Research Area/Cell Biology/Cell Adhesion & Migration/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Extracellular Matrix/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Signal Transduction/Abs For Paraffin Embedded Tissue; Research Area/Disease/Melanoma/Abs For Paraffin Embedded Tissue; Research Area/Glycobiology/Proteoglycans/Abs For Paraffin Embedded Tissue; Glycobiology/Proteoglycans/Abs For Paraffin Embedded Tissue; Glycobiology/Proteoglycans/Primary Antibodies; Antibodies/Primary Antibodies/Proteoglycans; Antibodies/Proteoglycans/Primary Antibodies; Research Area/Cell Biology/Cell Proliferation/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Cell Proliferation/Primary Antibodies; Research Area/Development/Angiogenesis/Abs For Paraffin Embedded Tissue; Research Area/Development/Angiogenesis/Primary Antibodies; Research Area/Cell Types/Glial Cells/Primary Antibodies; Research Area/Cell Types/Glial Cells/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Cell Differentiation/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Cell Differentiation/Primary Antibodies

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene. CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. CSPG4/NG2 is also a hallmark protein of oligodendrocyte progenitor cells (OPCs) and OPC dysfunction has been implicated as a candidate pathophysiological mechanism of familial schizophrenia. A research group investigating the role of genetics in schizophrenia, reported, two rare missense mutations in CSPG4 gene, segregating within families (CSPG4A131T and CSPG4V901G mutations). The researchers also demonstrated that induced pluripotent stem cells(iPSCs)-derived OPCs from CSPG4A131T mutation carriers exhibited abnormal post-translational processing, subcellular localization of the mutant NG2 protein, aberrant cellular morphology, and decreased cell viability and myelination potential. In vivo diffusion tensor imaging of the brain of CSPG4A131T mutation carriers demonstrated reduced white matter integrity compared to unaffected siblings and matched general population controls.

Monoclonal