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Recombinant Human Interleukin 2 (a. a. 134) Polypeptide

Recombinant Human Interleukin 2 (a. a. 134) Polypeptide

Item no.	DAG311
Manufacturer	Creative Diagnostics
Amount	50 ug
Category	Oncology Peptides & Proteins Cell Biology Cell Culture Cytokines Peptides By Organ Heart & Blood Cancer Thyroid Cancer
Type	Peptides
Format	Lyophilized
Specific against	other
Purity	>98%pure (RP-HPLC and SDS-PAGE). Purified by chromatographic techniques Productis sterile filtered.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-2,TCGF,lymphokine,interleukin-2,aldesleukin,OTTHUMP00000164090,T cellgrowth factor,involved in regulation of T-cell clonal expansion,IL2,interleukin 2,lymphokine,Aldesleukin,involved in regulation of T-cell clonal expansion
Available
Manufacturer - Applications	The ED50as determined by the dose-dependent stimulation of mouse CTLL-2 cells is lessthan 0.0645ng/ml, corresponding to a specific activity of 16.9 MIU/mg. Eachlaboratory should determine an optimum working titer for use in itsparticular application. Other applications have not been tested but use insuch assays should notnecessarily be excluded.
Storage Conditions	Thelyophilized product, though stable for 3 weeks at room temperature, is beststored at –20°C. After reconstitution, short term (up to 1 week) store at2-8oC. Long term, add 0.1% HSA or BSA, aliquot and store at –20°C. Avoidmultiple freeze/thaw cycles.
Full name	Interleukin 2
Product Overview	Recombinant Human IL-2 is a single non-glycosylatedmutein (variant form) of human IL-2 polypeptidechain containing 134 aminoacids and having a molecular weight of 15, 517 Da. The sequence of the first fiveN-terminal amino acids was determined to be Met-Ala-Pro-Thr-Ser. RecombinantHuman IL- 2 has a Ser substitute for Cysteine at position 126.
Abbr	IL2 (a.a. 134)
Manufacturer - Format	Purified, Lyophilized. Reconstitute using 20mM acetic acid to a concentration>=100ug/ml. Further dilutions can be madein other aqueous buffers.
Buffer	Lyophilized fromwater containing 0.17mg/ml Sodium Monobasic and 0.89mg/ml Dibasic Sodium. PhosphateBuffer, pH 7.5
Concentration	1.1mg/ml (OD280nm, E0.1% =0.614) (prior to lyophilization)
Preservative	None
Gene Information - Gene Name	IL2interleukin 2 [ Homo sapiens ]
Gene Information - mRNA Refseq	NM_000586
Gene Information - Protein Refseq	NP_000577
Gene Information - MIM	147680
Gene Information - Pathway	Allograft rejection, Autoimmune thyroid disease, Calcineurin-regulated NFAT-dependenttranscription in lymphocytes, Cytokine Signaling in Immune system, Graft-versus-host disease, HTLV-I infection
Gene Information - Function	kappa-type opioidreceptor binding, kinase activator activity, carbohydrate binding, cytokineactivity, glycosphingolipid binding, growth factor activity, interleukin-2receptor binding
Antigen Description	Interleukin-2 (IL-2)is an interleukin, a type of cytokine immune system signaling molecule, whichis a leukocytotrophic hormone that is instrumental in the body"s naturalresponse to microbial infection and in discriminating between foreign(non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible forimmunity.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/18/2025

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