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Recombinant Human Leptin (a. a. 146) Polypeptide

Recombinant Human Leptin (a. a. 146) Polypeptide

Item no.	DAG332
Manufacturer	Creative Diagnostics
Amount	1 mg
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Obesity Endocrine Regulation of Lipid Metabolism Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Purity	>95% pure (RP-HPLC and SDS-PAGE). Purified by chromatographictechniques Product is sterile filtered.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	LEP,leptin,OB, OBS, FLJ94114, obese protein, obesity factor, OTTHUMP00000212285, obese,mouse, homolog of, leptin (murine obesity homolog), leptin (obesity homolog,mouse), LEP_HUMAN, Leptin Murine Obesity Homolog, Leptin Precursor ObesityFactor, Obese Protein, Obesity, Obesity factor, Obesity homolog mouse,Obesity Murine Homolog Leptin
Available
Manufacturer - Applications	The ED50 calculatedby the Leptin-dependant stimulation of Human OB-R transfected mouse BaF3indicator cells is 0.5-1.6ng/ml. Each laboratory should determine an optimumworking titer for use in its particular application. Other applications havenot been tested but use in such assays should not necessarily be excluded.
Storage Conditions	The lyophilized product, thoughstable for 3 weeks at room temperature, is best stored at –20°C. Afterreconstitution, store at 2-8oC.
Full name	Leptin
Product Overview	RecombinantHuman Leptin is a single non-glycosylated polypeptide chain containing 146amino acids and having a molecular weight of 16 kDa. The sequence of thefirst five N-terminal amino acids was determined to beAla-Val-Pro-Ile-Gln.
Abbr	LEP (a.a. 146)
Manufacturer - Format	Purified, Lyophilized, Reconstitute in water. Further dilutions can be made in otheraqueous buffers.
Buffer	Lyophilized from 0.0045mM NaHCO3
Concentration	1mg/ml (OD280nm, E0.1% = 0.878) (prior tolyophilization)
Preservative	None
Gene Information - Gene Name	LEP leptin [ Homo sapiens ]
Gene Information - mRNA Refseq	NM_000230
Gene Information - Protein Refseq	NP_000221
Gene Information - MIM	164160
Gene Information - Pathway	Adipocytokinesignaling pathway, Cytokine-cytokine receptor interaction, Diabetes pathways, HIF-1-alpha transcription factor network, Incretin Synthesis, Secretion, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction, Regulation of Insulin Secretion, Synthesis, Secretion, and Deacylation ofGhrelin
Gene Information - Function	growth factoractivity, hormone activity, peptide hormone receptor binding
Antigen Description	Leptin (Greek leptosmeaning thin) is a 16 kDa protein hormone that plays a key role in regulatingenergy intake and energy expenditure, including appetite and metabolism. Itis one of the most important adipose derived hormones. The Ob(Lep) gene (Obfor obese, Lep for leptin) is located on chromosome 7 in humans

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 10/9/2025

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