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Recombinant Human Brain-Derived Neurotrophic Factor Polypeptide (a. a. 338)

Recombinant Human Brain-Derived Neurotrophic Factor Polypeptide (a. a. 338)

Item no.	DAG338
Manufacturer	Creative Diagnostics
Amount	10 ug
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Peptides & Proteins Obesity Peptides By Organ Heart & Blood Cancer Neuronal Cell Markers
Type	Peptides
Format	Lyophilized
Specific against	other
Purity	>96% pure (HPLC and SDS-PAGE). Endotoxin level is less than0.1ng/ug (IEU/ug). Purified by chromatographic techniques. Product is sterilefiltered.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	BDNF, Brain-DerivedNeurotrophic Factor, MGC34632, abrineurin, neurotrophin, OTTHUMP00000232005,OTTHUMP00000232006, OTTHUMP00000232013, OTTHUMP00000232014,OTTHUMP00000232015, OTTHUMP00000232016, OTTHUMP00000232018,OTTHUMP00000232019, OTTHUMP00000232020, OTTHUMP00000232021,OTTHUMP00000232022, OTTHUMP00000232039, OTTHUMP00000232040,OTTHUMP00000232041, OTTHUMP00000232043, Abrineurin
Available
Manufacturer - Applications	The ED50 as determined by the dose dependentinduction of ACHE (acetylcholine esterase) in rat basal forebrain primaryseptal culture is 50ng/ml. Each laboratory should determine an optimumworking titer for use in its particular application. Other applications havenot been tested but use in such assays should not necessarily be excluded.
Storage Conditions	The lyophilized product, though stable for 3 weeks at roomtemperature, is best stored at –20°C. After reconstitution, short term (up to1 week) store at 2-8oC. Long term, add 0.1% HSA or BSA, aliquot and store at–20°C. Avoid multiple freeze/thaw cycles.
Full name	Brain-Derived Neurotrophic Factor
Product Overview	Recombinant Human Brain-Derived Neurotrophic Factor is ahomodimer, non-glycosylated, polypeptide chain containing 2 x 119 amino acidsand having a total molecular weight of 26, 984 Da, was expressed in E. coli. Thesequence of the first five N-terminal amino acids was determined to beMet-His-Ser-Asp-Pro. Contains less than 1% dimers and aggregates.
Abbr	BDNF
Manufacturer - Format	Purified, Lyophilized Reconstitute using sterile deionized waterto a concentration>=100ug/ml. Further dilutions can be made in other aqueousbuffers.
Buffer	Lyophilizedfrom 20mM Sodium citrate buffer, pH 5.0
Concentration	1mg/ml(OD280nm, E0.1% = 1.6) (prior to lyophilization)
Preservative	None
Gene Information - Gene Name	BDNFbrain-derived neurotrophic factor [ Homo sapiens ]
Gene Information - mRNA Refseq	NM_001143805
Gene Information - Protein Refseq	NP_001137277
Gene Information - MIM	113505
Gene Information - Pathway	Huntington"sdisease, MAPK signaling pathway, Neurotrophic factor-mediated Trk receptorsignaling, p75(NTR)-mediated signaling
Gene Information - Function	growthfactor activity
Antigen Description	Major regulator ofsynaptic transmission and plasticity at adult synapses in many regions of theCNS. The versatility of BDNF is emphasized by its contribution to a range ofadaptive neuronal responses including long-term potentiation (LTP), long-termdepression (LTD), certain forms of short-term synaptic plasticity, as well ashomeostatic regulation of intrinsic neuronal excitability.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 10/9/2025

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