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Recombinant Mouse Leptin (a. a. 147) Polypeptide

Recombinant Mouse Leptin (a. a. 147) Polypeptide

Item no.	DAG294
Manufacturer	Creative Diagnostics
Amount	1 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Obesity Endocrine Regulation of Lipid Metabolism Peptides By Organ Heart & Blood Cancer
Type	Peptides
Format	Lyophilized
Specific against	other
Purity	>97%pure (HPLC, FPLC and reducing and non-reducing SDS-PAGE). Endotoxin level isless than 0.1ng/ug (IEU/ug). Purified by chromatographic techniques. Productis sterile filtered.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ob,obese, Lep, leptin, obesity factor, OTTMUSP00000050551, Obesity MurineHomolog Leptin, Obesity homolog mouse, LEP, FLJ94114, OB, OBS
Available
Manufacturer - Applications	Biological activity of Mouse Leptin is performed in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitonealinjection once daily at a dose of 5ug Leptin/gram body weight for a period of14 days. Significant effects on body weight, food consumption and plasmaglucose levels were observed to saline-treated controls. Each laboratoryshould determine an optimum working titer for use in its particularapplication. Other applications have not been tested but use in such assaysshould not necessarily be excluded.
Storage Conditions	Thelyophilized product, though stable for 3 weeks at room temperature, is beststored at –20°C. After reconstitution, short term (up to 1 week) store at2-8oC. Long term, add 0.1% HSA or BSA, aliquot and store at –20°C. Avoidmultiple freeze/thaw cycles.
Full name	Leptin
Product Overview	Recombinant MouseLeptin is a single, non-glycosylated, polypeptide chain containing 147 aminoacids and having a molecular weight of 16, 240 Da, was expressed in E.coli. Thesequence of the first five N-terminal amino acids was determined to beMet-Val-Pro-Ile-Gln. Contains less than 1% dimers and aggregates.
Abbr	Lep (a.a. 147)
Manufacturer - Format	Purified, Lyophilized. Reconstitute using sterile deionized water to a concentration >=100ug/ml.Further dilutions can be made in other aqueous buffers.
Buffer	Lyophilizedfrom 50mM NH4HCO3, pH 8.0
Concentration	1mg/ml (OD280nm, E0.1%= 0.201) (prior to lyophilization)
Preservative	None
Gene Information - Gene Name	Lepleptin [ Mus musculus ]
Gene Information - mRNA Refseq	NM_008493
Gene Information - Protein Refseq	NP_032519
Gene Information - Pathway	Adipocytokine signalingpathway, Adipocytokine signaling pathway, Adipogenesis, Cytokine-cytokinereceptor interaction
Gene Information - Function	growth factor activity, hormone activity, peptide hormonereceptor binding, protein binding
Antigen Description	Leptin plays a critical role in theregulation of body weight by inhibiting food intake and stimulating energyexpenditure. Defects in Leptin production cause severe hereditary obesity inrodents and humans. In addition to its effects on body weight, leptin has avariety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response.
Gene Information - Offical Symbol	Lep

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 10/9/2025

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