Recombinant Human Pregnancy Associated Plasma Protein A, dimeric

aliquot and store at -70°C. Avoid multiple freeze/thawcycles.

HumanPregnancy Associated Plasma Protein A, dimeric (dPAPP-A), Recombinant

Affinity Purified, Liquid

Lot specific dPAPP-A concentrationwas determined by DELFIA sandwich immunoassay using human heterotetrameric complexof PAPP-A as a calibrator.

PAPPApregnancy-associated plasma protein A, pappalysin 1 [ Homo sapiens ]

NP_002572

Diabetes pathways, Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-likeGrowth Factor Binding Proteins (IGFBPs)

Pregnancy-associated plasma protein A, pappalysin 1, alsoknown as PAPPA, is a protein used in screening tests for Down syndrome. Thisgene encodes a secreted metalloproteinase which cleaves insulin-like growthfactor binding proteins (IGFBPs). It is thought to be involved in localproliferative processes such as wound healing and bone remodeling. Low plasmalevel of this protein has been suggested as a biochemical marker forpregnancies with aneuploid fetuses (fetuses with an abnormal number ofchromosomes). For example, low PAPPA may be seen in prenatal screening forDown syndrome.