Recombinant Mouse Plasminogen Activator, Urokinase

Specificmethodologies have not been tested using this product.

Plasminogen Activator, Urokinase

Plau

0.05M Sodiumacetate, 0.1M Sodium chloride, 1mM EDTA, pH 5.0

None

NM_008873

Blood ClottingCascade, Complement and Coagulation Cascades, Dissolution of Fibrin Clot, Endochondral Ossification, Hemostasis, Wnt Signaling Pathway

Urokinase-type plasminogen activatoris an enzyme that in humans is encoded by the PLAU gene. This gene encodes aserine protease involved in degradation of the extracellular matrix andpossibly tumor cell migration and proliferation. A specific polymorphism inthis gene may be associated with late-onset Alzheimer disease and also withdecreased affinity for fibrin-binding. The protein encoded by this geneconverts plasminogen to plasmin by specific cleavage of an Arg-Val bond inplasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasminto form a two-chain derivative in which a single disulfide bond connects theamino-terminal A-chain to the catalytically active, carboxy-terminal B-chain.This two-chain derivative is also called HMW-uPA (high molecular weight uPA).HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) bycleavage of chain A into a short chain A (A1) and an amino-terminal fragment.LMW-uPA is proteolytically active but does not bind to the uPA receptor.