Human IL-1alpha ELISA Kit

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human IL-1alpha. The Human IL-1alpha ELISA is for research use only. Not for diagnostic or therapeutic procedures. Interleukin-1 (IL-1) is an extracellular peptide of 17 kDa that designates two proteins, IL-1alpha and IL-1beta. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis.IL-1alpha inhibitors are being developed to interrupt those processes and treat diseases.IL-1alpha is produced mainly by activated macrophages, as well asneutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha. IL-1alpha has been administered to patients during receiving autologous bone marrow transplantation. There is currently a head and neck phase III trial being run by Cel-Sci Corp. involving IL-1alphaand many other interleukins (Multikine) as an immunotherapy. In dermatology and cosmetics topical IL-1alpha has been shown to increase the production of collagen and other components of the dermal matrix.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

0.52 pg/ml

81 % - 106 %

n.d.

2.5 % - 4.4 %