Human IL-1beta ELISA Kit

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human IL-1beta. The Human IL-1beta ELISA is for research use only. Not for diagnostic or therapeutic procedures. Interleukin-1 (IL-1) is an extracellular peptide of 17 kDa that designates two proteins, IL-1alpha and IL-1beta. IL-1beta is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.The interleukin-1 (IL-1) species represent an important family of biologically active mono nuclear cell-derived proteins which are involved in inflammatory reactions and in immune responses. Increased production of IL-1beta causes a number of different autoinflammatory syndromes, most notably the monogenic conditions referred to as CAPS, due to mutations in the inflammasome receptor NLRP3 which triggers processing of IL-1beta.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

0.15 pg/ml

94 % - 113 %

n.d. - 6.61 pg/ml

4.7 % - 6.1 %