Angiotensinogen / AGT / SerpinA8 ELISA Kit, Human

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human AGT. The Human Angiotensinogen/AGT/SerpinA8 ELISA is for research use only. Not for diagnostic or therapeutic procedures. Angiotensinogen (AGT), also known as SerpinA8, is a member of the serpin family. It is an alpha-2-globulin produced constitutively and released into the circulation mainly by the liver. AGT is an essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. AGT is cleaved into three chains: Angiotensin-1, Angiotensin-2, and Angiotensin-3. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

312.50 - 20000 pg/ml

100% (n=30)

3.7 % - 4.5 %