Apolipoprotein E / Apo E ELISA Kit, Human

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human Apo E. The Human Apolipoprotein E /Apo E ELISA is for research use only. Not for diagnostic or therapeutic procedures. Apolipoprotein E (Apo E) is a class of apolipoprotein found in the chylomicron and Intermediate-density lipoprotein that is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. In peripheral tissues, Apo E is primarily produced by the liver and macrophages, and mediates cholesterol metabolism in an isoform-dependent manner. In the central nervous system, Apo E is mainly produced by astrocytes, and transports cholesterol to neurons via Apo E receptors. Apo E transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. In the field of immune regulation, a growing number of studies point to Apo E's interaction with many immunological processes, including suppressing T cell proliferation, macrophage functioning regulation, lipid antigen presentation facilitation to natural killer T cell as well as modulation of inflammation and oxidation. The secretion of Apo E by monocytes is down regulated by inflammatory cytokines and upregulated by TGF-beta. This protein is involved in Alzheimer’s disease and cardiovascular disease.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

1.71 pg/ml

1.9 - 148.0 ug/ml

3.5 % - 5.0 %