Apolipoprotein J / Apo J ELISA Kit, Human

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human Apo J. The Human Apolipoprotein J /Apo J ELISA is for research use only. Not for diagnostic or therapeutic procedures. Apolipoprotein J (Apo J), also known as clusterin, is a 75 - 80 kDa disulfide-linked heterodimeric protein. It is a molecular chaperone responsible for aiding protein folding of secreted proteins, and its three isoforms have been differentially implicated in pro- or antiapoptotic processes. Overexpression of the secretory Apo J isoform protects the cell from apoptosis induced by cellular stress, such as chemotherapy, radiotherapy, or androgen/estrogen depletion. Apo J promotes cell survival by a number of means, including inhibition of BAX on the mitochondrial membrane, activation of the phosphatidylinositol 3-kinase/protein kinase B pathway, promotion of angiogenesis, and mediation of the nuclear factor kappa B (NF-kappaB) pathway. Apo J is involved in many diseases related to oxidative stress, including neurodegenerative diseases, cancers, inflammatory diseases, and aging. Studies have suggested that people who already have Alzheimer's disease have more Apo J in their blood, and Apo J levels in blood correlate with faster cognitive decline in individuals with Alzheimer's disease.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

2.08 ng/ml

30.8 - 54.0 mg/ml

4.6 % - 4.9 %