Human MMP-7 ELISA Kit

Three samples were tested on one plate

3-4h

Matrix metalloproteinase-7 (MMP-7) also known as matrilysin, pump-1 protease (PUMP-1), or uterine metalloproteinase is an enzyme that in humans is encoded by the MMP7gene. MMP-7 are commonly expressed in epithelial cells including ductal epithelium of exocrine glands in skin, salivary glands, pancreas, glandular epithelium of intestine and reproductive organ, liver, and breast. In addition, MMP7 is highly expressed in the luminal surface of dysplastic glands in human colorectal cancers. The expression of MMP7 is regulated by the Wnt/β catenin signaling pathway, and mediated by transformation growth factor β (TGF-β). The primary role of cleaved/activated MMP7 is to break down extracellular matrix by degrading macromolecules including casein, type I, II, IV, and V gelatins, fibronectin, and proteoglycan. The activated MMP-7 can cleave the propeptides of proMMP-2 and proMMP-9 to facilitate tumor invasion.

Online product mannual

solid

0.02% sodium azide

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of rat VEGF. The Rat VEGF ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Vascular endothelial growth factor (VEGF) is a sub-family of growth factors, to be specific, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the denovoformation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).VEGF is a signal protein produced by cells that imulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. VEGF is best known for its role in vasculogenesis. During embryogenesis, VEGF regulates the proliferation, migration, and survival of endothelial cells, thus regulating blood vessel density and size, but playing no role in determining vascular patterns.
Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as bevacizumab and Ranibizumab can inhibit VEGF and control or slow those diseases.

Online product mannual

Online product mannual

100µL

Colorimetric